Nonanodioic acid 1-dodecyl ester (CAS 94109-08-7) é uma impureza lipofílica com ocorrência em processos de esterificação e síntese de ésteres | cuja baixa polaridade favorece sua persistência em fases orgânicas e potencial interferência em ensaios de pureza e estabilidade; pode sofrer hidrólise reversível gerando ácido nonanodioico e dodecanol | afetando perfis de degradação. O controle analítico recomenda-se por CLAE com detecção UV e espectrometria de massa ou por GC-MS após derivatização | complementado por métodos de purificação como cromatografia em coluna e extração líquido-líquido otimizada. Estabeleça limites baseados em risco analítico e avaliação toxicológica.
Referências
Nazzaro-Porro, Marcella. “Azelaic Acid.†Journal of the American Academy of Dermatology, vol. 17, no. 6, 1 Dec. 1987, pp. 1033–1041, www.sciencedirect.com/science/article/abs/pii/S0190962287702941, 10.1016/S0190-9622(87)70294-1. Accessed 28 Jan. 2022.
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