Eltrombopag amida (CAS 1246929-02-1) é uma impureza relacionada estruturalmente ao princípio ativo | caracterizada por um núcleo biphenyl substituído com um grupo carboxamida e um substituinte hidrazinilido tipo (Z) ligado a um anel pirozolona dimetilado. Essa impureza se forma tipicamente durante reações de acilação ou condensação e pode afetar perfil de pureza | constante de dissolução e estabilidade do insumo farmacêutico. A sua monitorização é recomendada por cromatografia líquida de alta eficiência com detecção UV e espectrometria de massas para identificação e quantificação. Controle robusto de processo e limites especificados asseguram conformidade regulatória e garantia de qualidade do lote.
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