N-Nitroso Nilotinib (CAS 2925306-68-7), também designado N-Nitroso Nilotinib Impurity 1, é uma impureza de პროცესso relacionada a nitrosaminas do inibidor de tirosina cinase nilotinib. Com fórmula molecular C28H21F3N8O2 e massa molecular de 558.53 g/mol, apresenta a função N-nitroso sobre um arcabouço heteroaromático altamente substituído, compatível com nitrosação durante a síntese ou por exposição de precursores amínicos a agentes nitrosantes. Por seu potencial caráter genotóxico, enquadra-se na avaliação de risco prevista em ICH M7. A caracterização confiável geralmente requer LC-MS/MS para quantificação em nível traço, apoiada por MS de alta resolução e, quando possível, confirmação ortogonal por LC-UV ou GC-MS.
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