N-Pivaloyl Amoxicillin (CAS 1313237-94-3) é uma impureza derivada da pivaloilação do grupo amino da amoxicilina | relevante em controlos de qualidade de matérias-primas e produtos acabados. Caracteriza-se por maior lipofilicidade e alteração do perfil de solubilidade que pode afetar pureza | rendimento e estabilidade do princípio ativo. Sua identificação e quantificação exigem métodos analíticos robustos como HPLC acoplada a detectores UV e LC-MS para separação e confirmação estrutural. A ocorrência costuma relacionar-se a impurezas de reagentes ou proteção incompleta durante síntese; estratégias de mitigação incluem otimização de etapas de desproteção | purificação e limites em especificações conforme orientações ICH.
Referências
Zhu, Yongxin, et al. “Evaluation of Liquid Chromatography Methods for the Separation of Ampicillin and Its Related Substances.†Journal of Pharmaceutical and Biomedical Analysis, vol. 14, no. 5, Mar. 1996, pp. 631–39, https://doi.org/10.1016/0731-7085(95)01661-9. ‌
Solicitar orçamento
"*" indica campos obrigatórios
Outros produtos relacionados às Amoxicillin impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
