Nilotinib Impurity E (HCl Salt) é uma impureza observada no processo de síntese e degradação do nilotinib | correspondente à 3-(2-methylimidazol-1-yl)-5-trifluoromethyl-phenylamine | também listada como 5-(2-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)benzenamine e Benzenamine | 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- (sal de HCl). A forma salina modifica solubilidade e comportamento cromatográfico | impactando retenção em HPLC. Identificação exige HPLC-UV | LC-MS para confirmação de massa e NMR para caracterização estrutural. Estudos de vias de formação | estabilidade e estratégias de controle de processo são fundamentais para limitar níveis residuais e garantir conformidade com especificações de qualidade.
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![3-{2-[(2-methyl-5-{[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbamoyl}phenyl)(nitroso)amino]pyrimidin-4-yl}pyridin-1-ium-1-olate](https://veeprho.com/wp-content/uploads/2024/11/VE0022222-3-2-2-methyl-5-3-4-methyl-1H-imidazol-1-yl-5-trifluoromethyl-phenyl-carbamoyl-phenyl-nitroso-amino-pyrimidin-4-yl-pyridin-1-ium-1-olate.png "3-{2-[(2-methyl-5-{[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbamoyl}phenyl)(nitroso)amino]pyrimidin-4-yl}pyridin-1-ium-1-olate")
