A impureza EP I de salbutamol, também designada impureza BP I de salbutamol e 4-Benzyl Albuterol, é uma impureza estrutural da família de agonistas β2 do albuterol, correspondente a um derivado éter arílico benzilado. Sua formação pode decorrer de desproteção incompleta, reações secundárias de alquilação ou arraste relacionado ao processo durante a síntese de intermediários de salbutamol. O composto, CAS 56796-66-8, apresenta fórmula molecular C20H27NO3 e massa molar de 329.43 g/mol. A caracterização normalmente exige LC-MS/MS ortogonal, HPLC com detecção por arranjo de diodos e, quando necessário, confirmação por RMN para distingui-lo de análogos fenoxipropanolamínicos e impurezas isoméricas traço.
Referências
Ullmann, N., et al. Salbutamol and Around.†Italian Journal of Pediatrics, vol. 41, no. Suppl 2, 2015, p. A74, https://doi.org/10.1186/1824-7288-41-s2-a74.
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