A impureza EP J do salbutamol, também denominada impureza BP J do salbutamol, salbutamone HCl ou Albuterol Related Compound B (sal de HCl), é o sal hidrocloreto de um análogo cetônico do salbutamol, CAS 41489-89-8. Com fórmula molecular C13H20ClNO3 e massa molar de 273,76 g/mol, trata-se de um produto de oxidação ou de transformação sintética resultante da conversão da função álcool benzílico no carbonilo correspondente. Essa impureza é relevante no perfil de impurezas de materiais beta2 agonistas e costuma exigir LC-MS/MS, HPLC com detecção por arranjo de fotodiodos e GC-MS confirmatório após derivatização.
Referências
Ullmann, N., et al. Salbutamol and Around.†Italian Journal of Pediatrics, vol. 41, no. Suppl 2, 2015, p. A74, https://doi.org/10.1186/1824-7288-41-s2-a74.
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