5-Nitroso-4H,5H,6H,7H-thieno[3,2-c]pyridin, auch als Clopidogrel-Nitroso-Impurität bezeichnet, ist eine nitrosierte heterozyklische Verunreinigung im Zusammenhang mit der Herstellung und Lagerung von Clopidogrel. Mit CAS 2460755-43-3, der Summenformel C7H8N2OS und einer Molmasse von 168,22 g/mol repräsentiert es die N-Nitrosierung des Thienopyridin-Gerüsts unter nitrosierenden Bedingungen oder aus Restnitritchemie. Als potenziell genotoxische Verunreinigung wird sie im regulatorischen Rahmen von ICH M7 bewertet. Die Bestimmung im Spurenbereich erfordert typischerweise LC-MS/MS, hochauflösende LC-MS und, sofern die Flüchtigkeit es zulässt, GC-MS.
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