Atorvastatin EP-Verunreinigung P, auch als Atorvastatin-Acetonid oder Atorvastatin-Verunreinigung-2 bezeichnet, CAS 581772-29-4, ist eine strukturell verwandte synthetische Prozessverunreinigung von Atorvastatin mit einem acetonidgeschützten Diolmotiv in der Seitenkette. Die Molekülformel lautet C36H39FN2O5 bei einer Molekülmasse von 598,70 g/mol. Diese Spezies entsteht typischerweise durch unvollständige Entschützung oder Nebenreaktionen während der semisynthetischen Herstellung und nicht primär durch oxidative Zersetzung. Aufgrund der engen strukturellen Nähe zum Wirkstoff erfordert die Charakterisierung meist LC-MS/MS, HPLC mit Diodenarraydetektion und bei Bedarf NMR zur positionsspezifischen Zuordnung. Sie wird im Rahmen des Verunreinigungsprofils bewertet und nicht als genotoxische Warnstruktur eingestuft.
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