Atorvastatin EP-Impurity F, auch als Atorvastatin-Amid-Säure, Di-Amid-Säure oder Diamino-Verunreinigung in freier Base bezeichnet, ist eine prozess- und degradationsbedingte verwandte Substanz, die mit der Atorvastatin-Synthese und Nebenreaktionen der Amidkupplung verknüpft ist. Sie entspricht CAS 887196-24-9, der Summenformel C40H48FN3O8 und einer Molekülmasse von 717,84 g/mol. Die Struktur weist auf Überaktivierung oder hydrolytische Umlagerung der Amidfunktion der Seitenkette hin, nicht auf eine klassische mutagene Warnstruktur. Die Charakterisierung erfordert typischerweise LC-MS/MS, hochauflösende MS sowie orthogonale HPLC-UV- oder LC-ELSD-Verfahren, bei Isolierung ergänzt durch NMR. Die Bewertung erfolgt im Rahmen des impurity profiling und der Spezifikationsfestlegung nach pharmakopöischen und ICH-Vorgaben.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
