Impureza (2-Clorofenil)(p-tolil)metanona (sinónimos: (2-chlorophenyl)-(4-methylphenyl)methanone; Methanone | (2-chlorophenyl)(4-methylphenyl)- | CAS 5953-00-4) es una cetona aromática orto-clorada que surge como subproducto en rutas de acoplamiento y acilación; presenta polaridad moderada y un cromóforo aromático que facilita su detección por HPLC-UV y GC-MS. Desde el punto de vista analítico puede provocar coelución con isómeros y sesgar rendimientos aparente si no se controla. Se recomienda control de calidad mediante HPLC con monitoreo a 254 nm | confirmación estructural por RMN y MS | y estrategias de purificación como cromatografía en columna o recristalización optimizada para garantizar especificidad y cuantificación precisa en perfiles de impurezas.
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