La impureza EP H de telmisartán, también denominada telmisartán bromo t-butil éster, CAS 114772-40-6, es un intermedio esterificado bromado asociado a la química de proceso del telmisartán y no un producto de degradación clásico. Su composición, C18H19BrO2, con peso molecular 347.25, corresponde a un armazón aromático bromado lipófilo que puede originarse por transformación incompleta o por reacciones secundarias durante la síntesis del antihipertensivo bipiridilo tetrazólico. Dado que las impurezas bromadas pueden persistir a niveles traza y modificar el perfil de impurezas, su caracterización suele requerir LC-MS/MS, LC-MS de alta resolución y HPLC-UV complementaria; GC-MS puede apoyar la evaluación de impurezas volátiles residuales. No es una nitrosamina.
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