Telmisartán EP Impurity B, también denominado Telmisartan Related Compound B o Telmisartan Isomer, es un isómero estructural del antagonista del receptor de angiotensina II con núcleo bifenilo tetrazol. El CAS 1026353-20-7 corresponde a una impureza isomérica neutra y no clásica, con fórmula molecular C33H30N4O2 y peso molecular 514.62 g/mol. Su aparición suele relacionarse con isomerización durante la ruta sintética o con reordenamientos tardíos, más que con degradación oxidativa. Dado que los isómeros posicionales pueden coeluir con el principio activo, su elucidación suele requerir LC-MS/MS, LC-MS de alta resolución y separación cromatográfica ortogonal, con confirmación por RMN cuando procede. Se controla como impureza relacionada con el proceso bajo criterios farmacopeicos.
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