La impureza A de Telmisartán EP, también denominada Telmisartán Related Compound A, CAS 152628-02-9, corresponde al precursor benzimidazólico desmetilado y desacidificado relacionado con el antagonista tetrazólico diarílico telmisartán. Estructuralmente es 1,7′-dimetil-2′-propil-2,5′-bibenzimidazol, con fórmula molecular C19H20N4 y peso molecular de 304.39 g/mol. Suele originarse como impureza relacionada con el proceso por alquilación incompleta del benzimidazol o por arrastre de intermedios sintéticos, más que por degradación oxidativa. Al carecer del farmacóforo ácido del principio activo, su control se enmarca en los requisitos farmacopéicos y en la evaluación de impurezas de ICH. Su detección y cuantificación suelen requerir LC-MS/MS, HPLC con detección por arreglo de diodos y, para confirmación estructural, RMN y espectrometría de masas de alta resolución.
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