La impureza D de Metoprolol EP, también denominada Metoprolol Related Compound E, es una impureza de proceso definida asociada al bloqueador betaadrenérgico metoprolol. El CAS 62572-90-1 corresponde a una especie orgánica neutra con fórmula molecular C12H18O4 y peso molecular de 226.27 g/mol. Desde el punto de vista estructural, se trata de un derivado de la cadena lateral hidroxilado y oxidado, no de una nitrosamina ni de otro armazón mutagénico reconocido. Su presencia suele relacionarse con reacciones secundarias de síntesis o con transformación oxidativa durante la fabricación y el almacenamiento. Su identificación y cuantificación a nivel traza عادة requieren LC-MS/MS, HPLC-UV y, cuando procede, confirmación por RMN bajo criterios farmacopéicos e ICH para el control de impurezas.
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