(αR)-3-Chloro-α-[(1S)-1-[(1, 1-dimethylethyl)amino]ethyl]-benzenemethanol and enantiomer
Sinónimos
rac erythro-Dihydrobupropion
Descripción
La impureza Bupropion Dihidro (R | S) Isómero y Enantiómero | CAS 99102-04-2 | también conocida como rac erythro-Dihydrobupropion | es un subproducto estereoquímico que puede formarse durante etapas de reducción en la síntesis de bupropion; su identificación y cuantificación son críticas para el control de calidad. Presenta retos analíticos por su naturaleza racémica | requiriendo cromatografía quiral y HPLC acoplado a espectrometría de masas | apoyados por RMN para confirmar configuración y pureza. Su presencia influye en el perfil de impurezas y estabilidad del lote | por lo que se recomiendan métodos validados | límites conforme a guías ICH y medidas de mitigación en proceso.
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