La impureza Citalopram Diol Desfluoro (CAS 1187671-15-3) es un derivado estructural relacionado con citalopram que puede generarse durante la síntesis o por degradación del principio activo. Su identificación y cuantificación son críticas para el control de calidad; suele caracterizarse por HPLC acoplada a detección UV y LC-MS | y confirmarse mediante RMN y espectrometría de masas de alta resolución. Su presencia afecta el perfil de impurezas y las especificaciones analíticas | por lo que requiere límites justificables y evaluación toxicológica conforme a guías ICH. Se recomienda mantener condiciones de almacenamiento estables y procedimientos de muestreo y limpieza validados para minimizar su formación.
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