El clorhidrato de L-lisina dietilamida, CAS 266356-00-7, es una impureza amídica básica de la cadena lateral de la lisina en la que los dos hidrógenos amino terminales están sustituidos por grupos etilo, dando la sal C10H25Cl2N3O con peso molecular de 274.23 g/mol. Su presencia puede derivarse de una N-etilación secuencial durante el acoplamiento amídico o de reactivos alquilantes residuales en la síntesis. Aunque no es una nitrosamina clásica, su estructura es relevante en el perfil de impurezas porque las especies catiónicas relacionadas con amidas terciarias pueden complicar el análisis a nivel traza. La cuantificación suele requerir LC-MS/MS, con confirmación ortogonal mediante LC-MS de alta resolución o cromatografía iónica.
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