Olaparib Impurity 33 (CAS 763114-26-7) es una impureza de proceso de pequeña molécula estructuralmente definida asociada al inhibidor de PARP olaparib, basado en piridazina. Con fórmula molecular C16H11FN2O3 y peso molecular de 298,27 g/mol, corresponde a un heterociclo aromático fluorinado con funcionalidad carbonílica y heteroatómica, compatible con un subproducto de síntesis o un producto de transformación originado durante el acoplamiento de intermedios de la ruta o por degradación oxidativa. Su evaluación suele requerir LC-MS/MS, espectrometría de masas de alta resolución y caracterización ortogonal por HPLC-UV, con RMN para confirmar la estructura. No constituye una clase clásica de alerta genotóxica, pero su control se enmarca en ICH Q3A y, cuando procede, ICH M7.
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