Olaparib Impurity 33 (CAS 763114-26-7) é uma impureza de प्रक्रिया estruturalmente definida, de baixa massa molecular, associada ao inibidor de PARP olaparibe, baseado em piridazina. Com fórmula molecular C16H11FN2O3 e massa molecular de 298,27 g/mol, trata-se de um heterociclo aromático fluorinado com funcionalidade carbonílica e heteroatômica, compatível com subproduto de síntese ou produto de transformação decorrente de acoplamento de intermediários da rota ou de degradação oxidativa. Sua avaliação normalmente emprega LC-MS/MS, espectrometria de massas de alta resolução e caracterização ortogonal por HPLC-UV, com RMN para confirmação estrutural. Não constitui uma classe clássica de alerta genotóxico, mas seu controle se enquadra em ICH Q3A e, quando aplicável, ICH M7.
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