Salbutamol EP Impurity C (CAS 18910-68-4) | conocida también como Salbutamol BP Impurity C | Levalbuterol Related Compound B | Albuterol Related Compound A | Salbutamol Deshydroxy Impurity o 3-Dehydroxy Salbutamol | es un producto de degradación identificado en procesos de síntesis y almacenamiento de salbutamol; químicamente se caracteriza por la pérdida de un grupo hidroxilo que altera polaridad y perfil cromatográfico. Su detección y cuantificación requiere métodos analíticos validados como HPLC con detección UV o MS. La evaluación de niveles | límites aceptables y estrategias de control son esenciales para garantizar cumplimiento de especificaciones farmacéuticas y estudios de estabilidad.
Referencias
Lavorini, Federico, et al. Clinical and Functional Responses to Salbutamol Inhaled via Different Devices in Asthmatic Patients with Induced Bronchoconstriction.†British Journal of Clinical Pharmacology, vol. 58, no. 5, Nov. 2004, pp. 512–20, https://doi.org/10.1111/j.1365-2125.2004.02185.x.
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