La impureza EP J de salbutamol, también denominada impureza BP J de salbutamol, salbutamone HCl o Albuterol Related Compound B (sal de HCl), es la sal hidrocloruro de un análogo cetónico del salbutamol, CAS 41489-89-8. Con fórmula molecular C13H20ClNO3 y peso molecular de 273,76 g/mol, corresponde a un producto de oxidación o de transformación sintética generado por la conversión del alcohol bencílico al grupo carbonilo correspondiente. Esta impureza es pertinente en el perfilado de impurezas de materiales beta2 agonistas y suele requerir LC-MS/MS, HPLC con detección por arreglo de fotodiodos y GC-MS confirmatorio tras derivatización.
Referencias
Ullmann, N., et al. Salbutamol and Around.†Italian Journal of Pediatrics, vol. 41, no. Suppl 2, 2015, p. A74, https://doi.org/10.1186/1824-7288-41-s2-a74.
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