Salbutamol EP Impurity H, también denominada Salbutamol Dideshydroxy Impurity (sal de HCl), es una impureza relevante en el control de calidad de lotes de salbutamol. Su pérdida de dos grupos hidroxilo modifica polaridad y solubilidad, afectando el perfil de retención en HPLC y la ionización en LC-MS. Se recomienda disponer de un estándar de referencia para cuantificación y validar métodos cromatográficos con límites de detección adecuados. Su formación puede deberse a reacciones durante síntesis o degradación en condiciones ácido básicas. El conocimiento de su espectro y comportamiento térmico facilita estrategias de purificación y límites de aceptación según monografías.
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