2-Amino-9-(((2-hydroxyethoxy)methoxy)methyl)-1,9-dihydro-6H-purin-6-one compound with 2-amino-9-((2-(hydroxymethoxy)ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (1:1)
Synonyms
N/A
Description
Acyclovir EP Impurity Q is a structurally related nucleoside impurity with formula C18H26N10O8 and molecular weight 510.46. Its composition indicates a heavily functionalized guanine-derived analogue, consistent with an oxidized or overacylated synthetic byproduct rather than a simple process residue. Such species may arise during multistep protection, glycosylation, or final deprotection sequences used in acyclovir manufacture. Because closely related purine impurities can affect assay specificity and impurity profiling, characterization typically requires reversed-phase LC coupled to high-resolution MS, often with MS/MS fragmentation support, and orthogonal LC-UV methods for trace-level resolution.
References
O’Brien, John J., and Deborah M. Campoli-Richards. “Acyclovir.†Drugs, vol. 37, no. 3, Mar. 1989, pp. 233–309, 10.2165/00003495-198937030-00002.
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