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560075-65-2Diclofenac EP Impurity F

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Catalogue No.:	VL48005
CAS No.:	560075-65-2
Mol. Formula:	C14H10Cl3NO
Mol. Weight:	314.59 g/mol

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Additional information on CAS 560075-65-2

Parent drug

Diclofenac

IUPAC Name

N-(4-chlorophenyl)-2-(2,6-dichlorophenyl)acetamide

Pharmacopeial Synonyms

Diclofenac Acetamide; Diclofenac Related Compound F

Synonyms

2,6-dichloro-n-(4-chlorophenyl)benzeneacetamide

Smiles

O=C(NC1=CC=C(Cl)C=C1)CC2=C(Cl)C=CC=C2Cl

InChI

InChI=1S/C14H10Cl3NO/c15-9-4-6-10(7-5-9)18-14(19)8-11-12(16)2-1-3-13(11)17/h1-7H,8H2,(H,18,19)

Shipping Condition

Ambient Temperature

Description

Diclofenac EP Impurity F, also designated Diclofenac Related Compound F or Diclofenac Acetamide, is the anilide acetamide analogue of diclofenac with CAS 560075-65-2, molecular formula C14H10Cl3NO, and molecular weight 314.59 g/mol. Structurally, it reflects amide formation at the phenylacetic side chain and is typically associated with synthetic or hydrolytic side reactions during diclofenac manufacture. Because the molecule contains three chloro substituents and a non-ionizable amide, trace-level assessment generally requires LC-MS/MS or LC-HRMS, often complemented by LC-UV and, where volatility permits, GC-MS confirmation. Its presence is relevant to impurity profiling and process characterization under pharmacopoeial and ICH impurity frameworks.

References

Sun, Wei, et al. “Crystal Structure of N-(4-Chlorophenyl)-2-(2, 6-Dichlorophenyl)Acetamide, C14H10Cl3NO.” Zeitschrift Für Kristallographie – New Crystal Structures, vol. 233, no. 5, Aug. 2018, pp. 913–14, https://doi.org/10.1515/ncrs-2018-0096 Todd, Peter A., and Eugene M. Sorkin. “Diclofenac Sodium.” Drugs, vol. 35, no. 3, Mar. 1988, pp. 244–85, https://doi.org/10.2165/00003495-198835030-00004.