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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

41411-66-9Doxycycline EP Impurity A (HCl Salt)

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Catalogue No.:	VE006390
CAS No.:	41411-66-9
Mol. Formula:	C22H25ClN2O8
Mol. Weight:	480.90 g/mol

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Additional information on CAS 41411-66-9

Parent drug

Doxycycline

IUPAC Name

(4S, 4aR, 5S, 5aR, 6S, 12aS)-4-(Dimethylamino)-3, 5, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydrotetracene-2-carboxamide HCl

Pharmacopoeial Synonyms

Doxycycline Related Compound A(HCl salt)

Other Synonyms

6-Epi Doxycycline

Smiles

C[C@H]1C2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl

InChI

InChI=1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);1H/t7-,10?,14-,15+,17+,22+;/m1./s1

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

Doxycycline EP Impurity A (HCl Salt) known in pharmacopoeias as Doxycycline Related Compound A(HCl salt) is a thoroughly characterized reference standard. It meets strict regulatory standards including those set by USP EMA JP and BP. This product is crucial for use in Abbreviated New Drug Applications (ANDA) New Drug Applications (NDA) and the commercial production of Doxycycline. Additionally it comes with a detailed Structure Elucidation Report (SER) ensuring its precision and dependability for a variety of analytical uses. Also known as Doxycycline Related Compound A or 6-Epi Doxycycline (HCl salt), it is from second generation Tetracycline class of antibiotics. It is a synthetic derivative of oxytetracycline. Its absorption decreases with the antacids.

References

‘Smith, Kelly, and James J. Leyden. “Safety of Doxycycline and Minocycline: A Systematic Review.” Clinical Therapeutics, vol. 27, no. 9, Sept. 2005, pp. 1329–42, https://doi.org/10.1016/j.clinthera.2005.09.005. ?Saivin, S., and G. Houin. “Clinical Pharmacokinetics of Doxycycline and Minocycline.” Clinical Pharmacokinetics, vol. 15, no. 6, Dec. 1988, pp. 355–66, https://doi.org/10.2165/00003088-198815060-00001. ?’