3963-95-9: Doxycycline EP Impurity B (HCl salt)

Doxycycline EP Impurity B (HCl salt) or Methacycline Impurity (CAS No.3963-95-9) or (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide HCl. It is from second generation Tetracycline class of antibiotics. It ia a synthetic derivative of oxytetracyclinre. Its absorption decreases with the antacids.

Additional information

Catalogue No.

VL159005

CAS No.

3963-95-9

Molecular Formula

C22H23ClN2O8

Molecular Weight

478.88

IUPAC Name

(4S, 4aR, 5S, 5aR, 12aS)-4-(Dimethylamino)-3, 5, 10, 12, 12a-pentahydroxy-6-methylene-1, 11-dioxo-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydrotetracene-2-carboxamide HCl

Synonyms

Methacycline Impurity

References

"Smith, Kelly, and James J. Leyden. “Safety of Doxycycline and Minocycline: A Systematic Review.” Clinical Therapeutics, vol. 27, no. 9, Sept. 2005, pp. 1329–42, https://doi.org/10.1016/j.clinthera.2005.09.005. ?Saivin, S., and G. Houin. “Clinical Pharmacokinetics of Doxycycline and Minocycline.” Clinical Pharmacokinetics, vol. 15, no. 6, Dec. 1988, pp. 355–66, https://doi.org/10.2165/00003088-198815060-00001. ?"

Status

In-stock