1246819-22-6: N-Nitroso Desloratadine

N-Nitroso Desloratadine (CAS No.: 1246819-22-6) or 8-Chloro-6,11-dihydro-11-(1-nitroso-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine is biotransformation of Desloratadine which is an orally potent peripheral histamine H1-receptor inhibitor and doesn’t have any sedative properties and is also evaluated for the treatment of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR) and chronic idiopathic urticaria (CIU).

Additional information

Catalogue No.

VE007389

CAS No.

1246819-22-6

Molecular Formula

C19H18ClN3O

Molecular Weight

339.82 g/mol

IUPAC Name

8-Chloro-6, 11-dihydro-11-(1-nitroso-4-piperidinylidene)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine

References

Brambilla, Giovanni, et al. “Genotoxicity and Carcinogenicity Studies of Antihistamines.” Archives of Toxicology, vol. 85, no. 10, Feb. 2011, pp. 1173–87, https://doi.org/10.1007/s00204-011-0659-4.?Murdoch, David, et al. “Desloratadine.” Drugs, vol. 63, no. 19, 2003, pp. 2051–77, https://doi.org/10.2165/00003495-200363190-00010.?

Status

In-stock