55-18-5: N-Nitroso Diethylamine (NDEA)
Also known as N,N-Diethylnitrous Amide or Nitrosodiethylamin, itit is DNA reactive after bioactivation and produces tumors in every animal species tested, bioactivation is affected by several P450 isozymes including CYP2E1 which is ethanol inducible, it has extensive use as a carcinogen.
Additional information on CAS 55-18-5
VL3850024
55-18-5
C4H10N2O
102.14
N/A
Diethylnitrosamine
N, N-Diethylnitrous Amide; N-Ethyl-N-nitrosoethanamine; DEN; DENA; Diethylnitrosamide; Diethylnitrosamine; Diethylnitrosoamine; N, N-Diethylnitrosoamine; N-Ethyl-N-nitrosoethanamine; N-Nitroso-N, N-diethylamine; NDEA; NSC 132; Nitrosodiethylamin; NDEA
Verna, L. “N-Nitrosodiethylamine Mechanistic Data and Risk Assessment: Bioactivation, DNA-Adduct Formation, Mutagenicity, and Tumor Initiation.” Pharmacology & Therapeutics, vol. 71, no. 1-2, 1996, pp. 57–81, https://doi.org/10.1016/0163-7258(96)00062-9.?Verna, L. “N-Nitrosodiethylamine Mechanistic Data and Risk Assessment: Bioactivation, DNA-Adduct Formation, Mutagenicity, and Tumor Initiation.” Pharmacology & Therapeutics, vol. 71, no. 1-2, 1996, pp. 57–81, https://doi.org/10.1016/0163-7258(96)00062-9
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