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137863-20-8Valsartan EP Impurity B

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Catalogue No.:	VL152003
CAS No.:	137863-20-8
Mol. Formula:	C31H35N5O3
Mol. Weight:	525.64 g/mol

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Additional information on CAS 137863-20-8

Parent drug

Valsartan

IUPAC Name

Benzyl (2S)-3-methyl-2-[pentanoyl[[2′-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]amino]butanoate

Pharmacopoeial Synonyms

Valsartan Related Compound C

Other Synonyms

Valsartan Benzyl Ester; L-Valine, N-(1-oxopentyl)-N-((2′-(2H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl)methyl)-, phenylmethyl ester; N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine Phenylmethyl Ester

Smiles

CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)OCC4=CC=CC=C4

InChI

InChI=1S/C31H35N5O3/c1-4-5-15-28(37)36(29(22(2)3)31(38)39-21-24-11-7-6-8-12-24)20-23-16-18-25(19-17-23)26-13-9-10-14-27(26)30-32-34-35-33-30/h6-14,16-19,22,29H,4-5,15,20-21H2,1-3H3,(H,32,33,34,35)/t29-/m0/s1

Description

Valsartan EP Impurity B, also designated Valsartan Related Compound C and Valsartan Benzyl Ester (Free Base), is the benzyl ester precursor of the valsartan tetrazole-containing biphenyl scaffold, CAS 137863-20-8. With molecular formula C31H35N5O3 and molecular weight 525.64 g/mol, it represents a synthetic intermediate or process-related byproduct arising from incomplete ester hydrolysis or carryover from benzyl-protected route chemistry. Its aromatic, lipophilic nature can complicate chromatographic resolution from the API. Trace determination typically requires reversed-phase HPLC with LC-MS/MS or high-resolution MS confirmation; orthogonal GC-MS may support volatile impurity profiling. It is not a nitrosamine, but remains relevant to impurity mapping and specification setting.