Metoprolol EP Impurity D は Metoprolol Related Compound E とも称される、メトプロロールに関連する既知の工程由来不純物である。CAS 62572-90-1 に対応し、分子式は C12H18O4、分子量は 226.27 g/mol である。構造的には、ニトロソアミンや既知の変異原性骨格ではなく、水酸化および酸化を受けた側鎖誘導体に分類される。通常、その生成は合成副反応または製造・保存中の酸化変換に起因する。微量レベルでの同定と定量には、LC-MS/MS、HPLC-UV、必要に応じて NMR による相補的確認が求められ、薬局方および ICH の不純物管理要件に整合する。
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