Metoprolol EP Impurity J, CAS 163685-37-8, is a structurally defined process-related impurity associated with the beta-adrenergic blocker metoprolol. With molecular formula C18H31NO5 and molecular weight 341.44 g/mol, it corresponds to a hydroxylated ether derivative bearing the secondary amino alcohol scaffold characteristic of metoprolol analogues. Its occurrence is typically linked to synthetic route variability, over-oxidation, or incomplete conversion during side-chain assembly rather than classical hydrolytic degradation. Structural discrimination generally requires LC-MS/MS, high-resolution MS, and orthogonal LC-UV or NMR confirmation for trace-level attribution and purity assessment in pharmacopeial impurity profiling.
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