QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.
説明
Nilotinib EP Impurity B, すなわち Nilotinib Related Compound B は、CAS 18595-18-1、分子式 C9H11NO2、分子量 165.19 g/mol を有する低分子の芳香族アミノアルコールに相当する。構造的には、ニトロソアミン類ではなく、置換ベンジルアミン骨格の構築に伴う合成中間体または製造由来副生成物と整合する。評価には、LC-MS/MS、高分解能MS、NMR による直交的同定が通常必要であり、揮発性が確保される場合は誘導体化後の GC-MS も有用である。規制上は、impurity profiling における特定関連物質として管理される。
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