Atorvastatin EP Impurity C, também designado Atorvastatin Related Compound C, Fluoroatorvastatin ou Atorvastatin Difluoro Analog, é uma impureza halogenada relacionada ao processo do inibidor da HMG-CoA redutase atorvastatina. A estrutura, CAS 693794-20-6, fórmula molecular C33H34F2N2O5 e massa molecular 576.64 g/mol caracterizam um análogo lipofílico difluorado, e não um simples produto de degradação. Sua formação é geralmente associada a reações laterais de fluorinação ou desproteção incompleta durante a síntese do fármaco. A identificação e a quantificação requerem tipicamente LC-MS/MS, LC-MS de alta resolução e métodos ortogonais de HPLC-UV, em conformidade com os princípios de ICH Q3A e Q3B.
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