Atorvastatin EP Impurity D (Impurity D1), também denominado Atorvastatin Epoxide, Atorvastatin Related Compound D ou Atorvastatin Epoxydione Impurity, é um degradante epoxídico oxidado associado à química da atorvastatina. O CAS 148146-51-4 corresponde a uma espécie neutra de fórmula C26H22FNO4 e massa molecular de 431.46 g/mol. Sua formação é normalmente relacionada à exposição a peróxidos, oxidação durante o armazenamento ou subprodutos de síntese que alteram a cadeia lateral heterocíclica. A confirmação estrutural exige, em geral, LC-MS/MS, espectrometria de massas de alta resolução e NMR complementar, enquanto a quantificação em nível traço depende de métodos de HPLC validados com detecção por UV e seletiva por massa.
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