Avatrombopag Nitroso Impurity 2 é uma impureza nitroso estruturalmente definida associada ao perfil de processo ou degradação do avatrombopag, situada no contexto de risco de nitrosaminas pela funcionalidade N-nitroso implícita na nomenclatura. Com fórmula molecular C11H12ClN5OS2 e massa molecular de 329,83 g/mol, apresenta um esqueleto heteroaromático clorado e heteroátomos de enxofre que influenciam polaridade, ionização e comportamento cromatográfico. Essas espécies são avaliadas sob a ótica da ICH M7 devido ao potencial de genotoxicidade. A detecção e a quantificação normalmente requerem LC-MS/MS, LC-MS de alta resolução e, quando a volatilidade permite, GC-MS.
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