Buspirone EP Impurity J, também designada Buspirone Open Ring Spirodimer Impurity, CAS 2726492-72-2, é uma impureza dimérica relacionada ao գործընթացo, associada ao arcabouço azapirônico espiracíclico da buspirona. A fórmula molecular C34H52N6O5 e a massa molecular de 624,81 g/mol indicam uma espécie de alta massa, não volátil, potencialmente formada por acoplamento sintético, abertura de anel ou rearranjos degradativos durante a fabricação ou o armazenamento. A elucidação estrutural normalmente requer LC-MS/MS de alta resolução com confirmação por RMN, pois a detecção por HPLC-UV convencional pode ser insuficiente em nível traço. Embora não seja uma nitrosamina, sua presença é relevante no perfil de impurezas farmacopéico e sob os princípios da ICH Q3A.
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