Empagliflozin Impurity 63, também designada Empagliflozin Benzylic keto Impurity ou Empagliflozin Impurity G, CAS 2125472-55-9, é uma impureza de processo clorada e oxigenada do arcabouço C-glicosídico do inibidor de SGLT2. Com fórmula molecular C23H25ClO8 e massa molecular de 464.89 g/mol, é compatível com oxidação benzílica ou formação de cetona na cadeia lateral ligada ao anel aromático durante síntese ou armazenamento. Sua polaridade e cromóforo aromático geralmente exigem LC-MS/MS, HPLC-DAD e espectrometria de massas de alta resolução para caracterização em nível traço, com confirmação estrutural por RMN. Não é uma impureza da classe das nitrosaminas e, em geral, não se enquadra como alerta estrutural na ICH M7.
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