Información adicional sobre el (6R | 7R)-7-((R)-2-((R)-2-((R)-2-amino-2-phenylacetamido)-2-phenylacetamido)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
El compuesto relacionado de cefalexina (6R | 7R)-7-((R)-2-((R)-2-((R)-2-amino-2-phenylacetamido)-2-phenylacetamido)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid es una impureza estructural que presenta retos analíticos y de control de calidad. Su núcleo beta-lactámico y los tres residuos fenilacetamido confieren carácter anfifílico | baja solubilidad en agua y comportamiento retenido en cromatografía reversa. La presencia de grupos amino y carboxilo genera estados ionizables que complican la separación y exige métodos validados por HPLC-UV y LC-MS | además de consideraciones quiral para evitar coeluciones con el principio activo. El control requiere estándares de referencia | condiciones de síntesis que minimicen racemización y procedimientos de purificación que garanticen cumplimiento de especificaciones y seguridad del producto final.
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![(6R,7R)-7-((R)-2-((R)-2-((R)-2-amino-2-phenylacetamido)-2-phenylacetamido)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid](https://veeprho.com/wp-content/uploads/2023/10/VE0015811-6R7R-7-R-2-R-2-R-2-amino-2-phenylacetamido-2-phenylacetamido-2-phenylacetamido-3-methyl-8-oxo-5-thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic-acid-sqr.png "(6R,7R)-7-((R)-2-((R)-2-((R)-2-amino-2-phenylacetamido)-2-phenylacetamido)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid")
