Clarithromycin Impurity G; 6-O-Methylerythromycin (9E)-9-(O-Methyloxime); Clarithromycin Impurity G; Clarithromycin EP Impurity G
Descripción
La impureza Clarithromycin Impurity G (CAS 127182-44-9) | conocida también como 6-O-Methylerythromycin (9E)-9-(O-Methyloxime) o Clarithromycin EP Impurity G | es un degradado relevante en el control de calidad de claritromicina. Se caracteriza por su masa molecular | polaridad intermedia | detectabilidad por HPLC-UV y confirmación por LC-MS. Suele formarse por metilación y oximación durante procesos de síntesis o almacenamiento | afectando el perfil de impurezas y requiriendo límites especificados en monografías. Se recomienda monitorizarlo mediante métodos validados de cromatografía líquida y espectrometría de masas | evaluar estabilidad y establecer especificaciones para garantizar conformidad farmacéutica.
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