La impureza Metoprolol Related Compound B (CAS 56718-76-4) | también identificada como 1-cloro-3-[4-(2-metoxietil)fenoxi]-2-propanol y su racemato | es un subproducto relevante en el perfil de impurezas del metoprolol. Se forma por rutas secundarias durante la síntesis o por degradación en condiciones de cloración y puede afectar la pureza farmacéutica si no se controla. Su detección y cuantificación se realiza típicamente mediante HPLC con detección UV | LC-MS y confirmación por RMN. Los programas de control de calidad aplican límites especificados | métodos de purificación y estudios de estabilidad para minimizar su presencia y asegurar cumplimiento regulatorio.
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