La impureza Telmisartan Bromo Amide (CAS 147404-72-6) es un subproducto halogenado que puede formarse durante etapas de síntesis de telmisartán por reacción incompleta o halogenación residual. Químicamente se caracteriza por un grupo amida bromado que altera polaridad | punto de fusión y perfil de fragmentación en espectrometría de masas. Su identificación y cuantificación se realizan mediante HPLC con detección UV y LC-MS | complementadas con RMN para confirmación estructural. El control analítico riguroso y los límites de aceptación basados en evaluación de riesgo garantizan la calidad farmacéutica | mientras que estrategias de purificación y optimización de proceso reducen su presencia en el material activo.
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