(3R, 5R)-7-(2-(4-fluorophenyl)-4-((2-hydroxyphenyl)carbamoyl)-5-isopropyl-3-(phenyl-d5)-1H-pyrrol-1-yl)-3, 5-dihydroxyheptanoic acid, calcium salt (2:1)
Sinônimos
N/A
Descrição
Ortho-Hydroxy Atorvastatin-D5 Calcium Salt (CAS 265989-47-7) é uma impureza isotópica de massa marcada que apresenta substituição de cinco átomos de hidrogênio por deutério na posição orto-hidroxilada do anel aromático | resultando em um deslocamento de massa observável por espectrometria de massas. Esta impureza pode surgir durante etapas de síntese e manipulação | exibindo comportamento cromatográfico ligeiramente diferente do composto não marcado e potenciais variações na estabilidade térmica e à luz. A detecção robusta requer métodos validados de LC-MS/MS com monitorização de traços específicos e parâmetros de fragmentação conhecidos. Estratégias de controle incluem limites de especificação | estudos de degradação e procedimentos de purificação documentados para garantir conformidade regulatória.
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