Atorvastatin Impurities

Atorvastatin is used along with a healthy diet to reduce blood cholesterol and triglyceride (fat) levels.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
ADK-1 (Atorvastatin Impurity) Atorvastatin

ADK-1 (Atorvastatin Impurity)

VL10038 124401-38-3
ADK-2 (Atorvastatin Impurity) Atorvastatin

ADK-2 (Atorvastatin Impurity)

VL10039 88675-31-4
Atorvastatin (3R,5S)-Isomer (Calcium Salt) Atorvastatin

Atorvastatin (3R,5S)-Isomer (Calcium Salt)

VE0012973 1312366-79-2
Atorvastatin 2,3-Anhydro lactone Atorvastatin

Atorvastatin 2,3-Anhydro lactone

VL10040 442851-50-5
Atorvastatin 3-Deoxy-Hept-2-Enoic Acid Atorvastatin

Atorvastatin 3-Deoxy-Hept-2-Enoic Acid

VL10018 N/A
Atorvastatin 3-Deoxy-Hept-2-Enoic Acid (Free Base) Atorvastatin

Atorvastatin 3-Deoxy-Hept-2-Enoic Acid (Free Base)

VE008374 1105067-93-3
Atorvastatin 3-Deoxyhept-2Z-Enoic Acid (Na Salt) Atorvastatin

Atorvastatin 3-Deoxyhept-2Z-Enoic Acid (Na Salt)

VE0012997 1659317-56-2
Atorvastatin Acetonide Impurity Atorvastatin

Atorvastatin Acetonide Impurity

VE006450 581772-29-4
Atorvastatin Acetonide Methyl Ester Impurity Atorvastatin

Atorvastatin Acetonide Methyl Ester Impurity

VL10037 1553049-81-6
Atorvastatin Acetonide t-Butyl Ester Side Chain (4R,6S)-Isomer Atorvastatin

Atorvastatin Acetonide t-Butyl Ester Side Chain (4R,6S)-Isomer

VE0015044 196085-84-4
Atorvastatin Acetonide t-Butyl Ester Side Chain (4S,6R)-Isomer Atorvastatin

Atorvastatin Acetonide t-Butyl Ester Side Chain (4S,6R)-Isomer

VE0015045 186508-95-2
Atorvastatin Acyl-β-D-glucuronide Atorvastatin

Atorvastatin Acyl-β-D-glucuronide

VE009572 463962-58-5
Atorvastatin Amlodipine Dimer Or Adduct Atorvastatin

Atorvastatin Amlodipine Dimer Or Adduct

VL10041 425408-16-8
Budesonide for System Suitability CRS (Y0001148) Atorvastatin

Atorvastatin calcium CRS (Y0002315)

PVE00106 N/A
Atorvastatin Calcium Impurity-J Atorvastatin

Atorvastatin Calcium Impurity-J

VE006263 N/A
Atorvastatin Calcium Impurity-P Atorvastatin

Atorvastatin Calcium Impurity-P

VE006264 N/A
Atorvastatin Dehydro Lactone (R-Isomer) Atorvastatin

Atorvastatin Dehydro Lactone (R-Isomer)

VE0011077 N/A
Atorvastatin Desfluoro Diol Ester Impurity Atorvastatin

Atorvastatin Desfluoro Diol Ester Impurity

VE009397 N/A
Atorvastatin Dibromo Impurity Atorvastatin

Atorvastatin Dibromo Impurity

VE008631 2514955-94-1
Atorvastatin Diepoxide Atorvastatin

Atorvastatin Diepoxide

VE006221 887470-43-1
Atorvastatin Diepoxide Calcium Salt Atorvastatin

Atorvastatin Diepoxide Calcium Salt

VL10014 N/A
Atorvastatin Diepoxide Lactone Impurity Atorvastatin

Atorvastatin Diepoxide Lactone Impurity

VE007949 1046118-40-4
Atorvastatin Diepoxy-Tetrahydropyranyl Atorvastatin

Atorvastatin Diepoxy-Tetrahydropyranyl

VL10036 196085-85-5
Atorvastatin Diketo Amide 2-Fluoro Analog Atorvastatin

Atorvastatin Diketo Amide 2-Fluoro Analog

VE008630 1797905-42-0
Atorvastatin EP Impurity A Atorvastatin

Atorvastatin EP Impurity A

VE008745 433289-84-0
Atorvastatin EP Impurity B (Free Base) Atorvastatin

Atorvastatin EP Impurity B (Free Base)

VE009319 842103-12-2
Atorvastatin EP Impurity C Atorvastatin

Atorvastatin EP Impurity C

VE008906 693794-20-6
Atorvastatin EP Impurity C (Na Salt) Atorvastatin

Atorvastatin EP Impurity C (Na Salt)

VE0012975 1807481-00-0
Atorvastatin EP Impurity D Atorvastatin

Atorvastatin EP Impurity D

VL10003 148146-51-4
Atorvastatin EP Impurity E (Calcium Salt) Atorvastatin

Atorvastatin EP Impurity E (Calcium Salt)

VL10006 1105067-88-6
Atorvastatin EP Impurity E (Free Base) Atorvastatin

Atorvastatin EP Impurity E (Free Base)

VE0012984 501121-34-2
Atorvastatin EP Impurity E (Na Salt) Atorvastatin

Atorvastatin EP Impurity E (Na Salt)

VE009244 1428118-38-0
Atorvastatin EP Impurity F (Ca Salt) Atorvastatin

Atorvastatin EP Impurity F (Ca Salt)

VL10011 1105067-87-5
Atorvastatin EP Impurity F (Free Acid) Atorvastatin

Atorvastatin EP Impurity F (Free Acid)

VE006369 887196-24-9
Atorvastatin EP Impurity F (sodium salt) Atorvastatin

Atorvastatin EP Impurity F (sodium salt)

VE006021 1371615-56-3
Atorvastatin EP Impurity G Atorvastatin

Atorvastatin EP Impurity G

VL10010 887196-29-4
Atorvastatin EP Impurity G Atorvastatin

Atorvastatin EP Impurity G

VE0017910 N/A
Atorvastatin EP Impurity G Atorvastatin

Atorvastatin EP Impurity G

VE009827 887324-53-0
Atorvastatin EP Impurity G (Diisopropyl Amine Salt) Atorvastatin

Atorvastatin EP Impurity G (Diisopropyl Amine Salt)

VE0011078 N/A
Atorvastatin EP Impurity H Atorvastatin

Atorvastatin EP Impurity H

VL10002 125995-03-1
Atorvastatin EP Impurity H-D5 Atorvastatin

Atorvastatin EP Impurity H-D5

DVE0055 N/A
Atorvastatin EP Impurity K Atorvastatin

Atorvastatin EP Impurity K

VL10009 345891-62-5
Atorvastatin EP Impurity O (Free Base) Atorvastatin

Atorvastatin EP Impurity O (Free Base)

VE009989 887196-30-7
Atorvastatin EP Impurity O (Na Salt) Atorvastatin

Atorvastatin EP Impurity O (Na Salt)

VL10007 1391052-00-8
Atorvastatin Epoxy Tetrahydrofuran Analog Atorvastatin

Atorvastatin Epoxy Tetrahydrofuran Analog

VL10030 873950-19-7
Atorvastatin Ethyl Ester impurity Atorvastatin

Atorvastatin Ethyl Ester impurity

VL10024 1146977-93-6
Atorvastatin for peak identification B CRS (Y0002304) Atorvastatin

Atorvastatin for peak Identification A CRS

PVE0017 N/A
Atorvastatin for peak identification B CRS (Y0002304) Atorvastatin

Atorvastatin for peak identification B CRS (Y0002304)

PVE0015 N/A
Atorvastatin FX1 Impurity Atorvastatin

Atorvastatin FX1 Impurity

VE008426 873950-18-6
Atorvastatin FX1 Impurity (Na Salt) Atorvastatin

Atorvastatin FX1 Impurity (Na Salt)

VL10021 1315629-79-8

Atorvastatin Related Compound

This medication may help avoid medical issues caused by fats obstructing blood arteries (for example, chest discomfort, heart attack, or stroke).

References

  • “Statins.” Heartuk.org.uk, 2023, www.heartuk.org.uk/getting-treatment/statins.
  • Nawrocki, James W., et al. “Reduction of LDL Cholesterol by 25% to 60% in Patients with Primary Hypercholesterolemia by Atorvastatin, a New HMG CoA Reductase Inhibitor.” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 5, May 1995, pp. 678–82, https://doi.org/10.1161/01.atv.15.5.678.
  • Bansal, Agam B., and ManouchkatheCassagnol. “HMG-CoA Reductase Inhibitors.” Nih.gov, StatPearls Publishing, 4 July 2022.

FAQ

How effective is atorvastatin?

Often, statins have excellent results. They can lower your LDL cholesterol by about 30%, and in certain cases, large dosages can even lower it by 50%.

How rapidly does atorvastatin reduce cholesterol levels?

Atorvastatin takes effect quickly; during the first two weeks of medication, LDL cholesterol was reduced by 90% from baseline.

What is the mechanism action of atorvastatin ?

The inhibition of hepatic cholesterol synthesis causes a decrease in cholesterol in theendoplasmic reticulum, which causes the movement of sterol regulatory element bindingproteins (SREBPs) from the endoplasmic reticulum to the golgi, where they are cleaved byproteases and converted into active transcription factors.