A Impureza EP I de buspirona, também denominada buspirona clorobuspirona, é uma impureza de processo clorada associada ao ansiolítico azaspirodecanediona buspirona. O CAS 2725354-99-2 corresponde a C21H30ClN5O2, com massa molecular de 419,95 g/mol. A presença de cloro indica um subproduto sintético halogenado ou produto de substituição formado em etapas intermediárias dependentes da rota ou por reação paralela. Sua resolução cromatográfica geralmente requer HPLC em fase reversa com confirmação por LC-MS/MS ou espectrometria de massas de alta resolução, e a atribuição estrutural pode ser apoiada por RMN. É tratada como impureza definida em perfis regulatórios e limites de especificação.
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