Di-Nitroso-Pyrrolopiperidine (DNPP) mit der Summenformel C7H12N4O2 und einer Molekülmasse von 184,20 g/mol ist eine Nitrosamin-Verunreinigung mit zwei N-Nitroso-Funktionen auf einem Pyrrolopiperidin-Gerüst. Solche Spezies entstehen typischerweise durch Nitrosierung von Amin-Vorstufen während der Synthese oder bei Kontakt mit nitrosierenden Reagenzien unter sauren Bedingungen und sind im Rahmen der Kontrolle genotoxischer Verunreinigungen gemäß ICH M7 zu bewerten. Aufgrund der Spurenkonzentration und des charakteristischen Ionisationsverhaltens erfolgt die Bestimmung meist mittels LC-MS/MS, hochauflösender LC-MS und, sofern die Volatilität ausreicht, GC-MS mit selektiver Ionenüberwachung. Die Strukturzuordnung erfordert häufig Tandem-Massenspektrometrie.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
