Abacavir Related Compound C (CAS 172015-79-1) es una impureza relacionada que se presenta como sal de clorhidrato del derivado de cloropurina con un sustituyente ciclopentenílico portador de un grupo metanol. Su estructura incorpora un núcleo 2-amino-6-cloro-9H-purina unido a un fragmento cyclopent-2-en-1-yl | lo que influye en su polaridad y comportamiento cromatográfico. En control de calidad se recomienda su detección y cuantificación por HPLC con detección por espectrometría de masas y confirmación mediante RMN. La evaluación de estabilidad | perfil de degradación y límites específicos conforme a normativas son esenciales para gestionar la pureza del principio activo.
Referencias
?Canoa, Pilar, et al. “Synthesis and Anti-HIV Activity of Novel Cyclopentenyl Nucleoside Analogues of 8-Azapurine.” Chemical and Pharmaceutical Bulletin, vol. 54, no. 10, 2006, pp. 1418–20, https://doi.org/10.1248/cpb.54.1418. ?
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