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172015-79-1Abacavir Related Compound C

● Under Development

Catalogue No.:	VL760026
CAS No.:	172015-79-1
Mol. Formula:	C11H13Cl2N5O
Mol. Weight:	302.16 g/mol

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Additional information on CAS 172015-79-1

Parent drug

Abacavir

IUPAC Name

(1S, 4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride

Pharmacopoeial Synonyms

N/A

Other Synonyms

ABACAVIR CHLOROPURINE DERIVATIVE; ((1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride; (1S-4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride; [(1S,4R)-4-(2-amino-6-chloropurin-9-yl)cyclopent-2-en-1-yl]methanol;hydrochloride; (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol HCl; [(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl]methanol Hydrochloride; [(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol–hydrogen chloride (1/1)

Description

Abacavir Related Compound C (CAS No: 172015-79-1) or Abacavir 6-Chloro Analog is an analog of Abacavir that is the first member of the carbocyclic nucleosides family to be recommended for use for HIV. Thus having anti-HIV activity comparable to that of carbolic against HIV-1 in MT-4 cells.

References

?Canoa, Pilar, et al. “Synthesis and Anti-HIV Activity of Novel Cyclopentenyl Nucleoside Analogues of 8-Azapurine.” Chemical and Pharmaceutical Bulletin, vol. 54, no. 10, 2006, pp. 1418–20, https://doi.org/10.1248/cpb.54.1418. ?