127252-80-6: Clarithromycin EP Impurity O
Clarithromycin EP Impurity O (CAS No: 127252-80-6) or 6-O-Methylerythromycin A (Z)-9-(O-methyloxime) is a chemical modification of erythromycin. Erythromycin is a macrolide that functions by blocking the translocation reaction at the time of protein synthesis. Erythromycin, except under alkaline conditions, is inactive against Enterobacteriaceae and Pseudomonas aeruginosa.
Additional information on CAS 127252-80-6
6-O-Methylerythromycin A (Z)-9-(O-methyloxime)
WATANABE, YOSHIAKI, et al. “Chemical Modification of Erythromycins. IX. Selective Methylation at the C-6 Hydroxyl Group of Erythromycin a Oxime Derivatives and Preparation of Clarithromycin.” The Journal of Antibiotics, vol. 46, no. 4, 1993, pp. 647–60, https://doi.org/10.7164/antibiotics.46.647. WASHINGTON, JOHN A., and WALTER R. WILSON. “Erythromycin: A Microbial and Clinical Perspective after 30 Years of Clinical Use (First of Two Parts).” Mayo Clinic Proceedings, vol. 60, no. 3, Mar. 1985, pp. 189–203, https://doi.org/10.1016/s0025-6196(12)60219-5.
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