138768-62-4: N-Nitroso Metoprolol
It is the impurity present in metoprolol that has been shown to decrease cardiovascular disease risk in patients with hypertension and type 2 diabetes mellitus and is advantageous in idiopathic dilated cardiomyopathy.
Additional information on CAS 138768-62-4
VE007073
138768-62-4
C15H24N2O4
296.36 g/mol
Metoprolol
N-(2-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl)-N-isopropylnitrous amide
N/A
Seshadri, Raja Kumar. “Simultaneous Quantitative Determination of Metoprolol, Atorvastatin and Ramipril in Capsules by a Validated Stability-Indicating RP-UPLC Method.” Scientia Pharmaceutica, vol. 78, no. 4, 2010, pp. 821–34, https://doi.org/10.3797/scipharm.1004-14. Bakris, George L., et al. “Metabolic Effects of Carvedilol vs Metoprolol in Patients with Type 2 Diabetes Mellitus and Hypertension.” JAMA, vol. 292, no. 18, Nov. 2004, p. 2227, https://doi.org/10.1001/jama.292.18.2227.
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